With experiments generally conducted on transmission electron microscopes, electron diffraction (ED) brings forth the ability to measure crystals in the range of tens to hundreds of nanometres in both direct (imaging mode) and reciprocal space (diffraction mode). As the analysis of crystal structures of new materials is as important as ever, there is the need from industry and academia to determine crystal structures of smaller crystal sizes than previously possible. With scientists in mind who don’t yet have an in-depth knowledge of 3D electron diffraction (3D ED) but a general understanding of X-ray diffraction methods, this article aims to provide an overview of the most important techniques, achievements, advantages, and challenges in the field. Four examples of data collected on an Eldico ED-1 are showcased to demonstrate the potential and advantages of a dedicated electron diffractometer, covering selected applications and challenges of electron diffraction: (i) multiple reciprocal lattices, (ii) absolute structure of a chiral compound, and (iii) R-values achieved by kinematic refinement comparable to X-ray data.
In addition to the ultra-high-speed hybrid-pixel detectors enabling ED data collection in continuous rotation mode, a high-precision goniometer and horizontal layout have been determined as essential features of an electron diffractometer, both of which are embodied in the Eldico ED-1. The recent introduction of dedicated instrumentation to perform ED experiments is a key aspect of the continued growth and success of this technology. Electron diffraction enables the characterization of solid compounds complementary to neutron, powder X-ray and single-crystal X-ray diffraction, as it has the unique capability to measure nanometre-sized crystals. The application of electron diffraction in performing nano-crystallography on crystals smaller than 1 µm is a disruptive technology that is opening up fascinating new perspectives for a wide variety of compounds required in the fields of chemical, pharmaceutical and advanced materials research. (2010), 43, 362-366.Electron diffraction (known also as ED, 3D ED or microED) is gaining momentum in science and industry. R., McCabe, P., Pidcock, E., Rodriguez-Monge, L., Taylor, R., van de Streek, J. PLATON: PLATON, A Multipurpose Crystallographic Tool, A. Bruker AXS Inc., Madison, Wisconsin, USA. Sweet, Academic Press.īruker: APEX3, SAINT, SADABS and XP. Minor, Processing of X-ray Diffraction Data Collected in Oscillation Mode, Methods Enzymol.
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